Presentation of retinoblastoma as phthisis bulbi eye. For these reasons, it is important to send enucleated phthisical eyes for histopathology. It is important to note that clinically this is called phthisis bulbi, although one of the main criteria of. Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in mark3. Prosthetic guidelines for ocular rehabilitation in patients with phthisis bulbi. It may result from severe eye disease, inflammation or injury, or it may represent a complication of eye surgery. Malignant melanoma and massive retinal gliosis in phthisis. Endophthalmitis was the final diagnosis rendered in 16 eyes 15 eviscerations and one enucleation over the above mentioned 20 year period. Phthisis bulbi is characterized by a severe irregular shrinkage of the eye. Enucleation for specimens with clinical histories such as phthisis bulbi procedure. Phthisis bulbi represents an ocular endstage disease characterized by shrinkage and disorganization of the eye.
When phthisis bulbi occurs after a penetrating injury, the eye is blind and shrinks, losing its normal architecture. Opthalmic pathology grossing guidelines specimen type. A 70yearold woman presented with a painless fleshy mass in the right eye of 3 months duration with no history of trauma. A retrospective survey of the ocular histopathology of the. As a consequence, the cornea becomes distorted and can develop edema and scarring, and the lens develops cataracts. Phthisis bulbi is defined as atrophy, shrinkage, and disorganization of the eye and intraocular contents. Blastomycosis cat enucleated in florida travel history includes missouri. Request pdf phthisis bulbi in retinoblastoma phthisis bulbi is a relatively uncommon and atypical clinical presentation of retinoblastoma. A total of 111 patients had bilateral rb, 2 of them presenting with phthisis bulbi and buphthalmos.
Figure 1 eye phthisis bulbi in a female b6c3f1 mouse from a chronic study. Risk factors for development of phthisis bulbi in patients. We aim at identifying the pathologic changes of phthisis bulbi associated with retinoblastoma. Histology, survivorship, and related factors in the epidemiology of eye cancers. Twenty eight eyes removed with a history of phthisis bulbi were sent for histology 22 evisceration specimens and six enucleated globes. Phthisis bulbi trauma cararact surgery, vitrectomy retinal pneumopexy, retinal reattachment surgery. Also called endstage eye, this condition is related to a variety of causes that lead to scarring, inflammation, and globe. Phthisis bulbi and buphthalmos are unusual presenting signs of rb. Eye pathology coplow gross pathology training 1 2016.
The eye should be refixed in 50% ethanol, after formalin fixation, for easier photography. Print two red cassettes and submit in the outer pocket of the specimen bag with the eye sections in a new specimen container to histology. Staphyloma and coats disease was the diagnosis in 31. We sought to determine the incidence of retinoblastoma patients who presented with phthisis bulbi. Phthisis bulbi and buphthalmos as presenting signs. Retrospective study conducted at a tertiary care hospital. Eye phthisis bulbi national toxicology program nih. Phthisis bulbi penyebab, gejala, dan pengobatan honestdocs. An ocular prosthetist makes use of this eye shrinkage to fit the artificial eye or shell within the orbit underneath the lids, so that it completely fills the orbit and the lids extend over the shell, giving the patient a normal. Clinical features, imaging studies, and histopathology. Juga disebut atrofi mata pengecilan bola mata stadium akhir, kondisi ini disebabkan oleh berbagai penyebab yang dapat menyebabkan timbulnya jaringan parut, peradangan, dan gangguan pada bola mata. Phthisis bulbi implies, in clinical terminology, a shrunken globe, usually from ceased aqueous humor formation phthisis meaning wasting away. Not all eyes rendered sightless by trauma become phthisical. Case 1 a 30monthold girl was referred to our center in 1987 for buphthalmos of the left eye and phthisis bulbi of the right eye.
Ocular histopathology of norries disease sciencedirect. Among those in the final category, 8 had only epithelial changes, 2 had only. Eye phthisis bulbi in a female b6c3f1 mouse from a lifetime study. Posterior and, less commonly, anterior cortical cataracts were noted both in older unexposed mice and. Treatment options include insertion of a prosthesis, which may be preceded by enucleation of the eye. Phthisis bulbi is an atrophic scarred, nonfunctional eye that may result from a variety of severe ocular conditions due to inflammation, trauma, or complication of an ocular surgery 7. Phthisis bulbi log in forgot password forgot email. Phthisis bulbi and buphthalmos as presenting signs of. Histopathology did not reveal\ud viable tumor cells in the phthisical eyes. Article pdf available in fetal and pediatric pathology 343 april 2015.
A retrospective survey of the ocular histopathology of the pinniped eye with emphasis on corneal disease. G manual of histologic staining methods of the armed forces institute of pathology. Ophthalmic pathology grossing guidelines specimen type. Enucleation for specimens with clinical histories such as phthisis bulbi. Prosthetic guidelines for ocular rehabilitation in. Clinical and pathologic findings in retinoblastoma. This can be seen in dogs and depending on the underlying cause, different ages and breeds are affected. Most common types of orbital rhabdomyosarcoma image. Ultrasonography in cases of phthisis bulbi springerlink. Phthisis bulbi results from such different ocular conditions as severe. Visual impairment and progressive phthisis bulbi caused by. Since 1985, in the department of ophthalmology, medical university of debrecen, we have examined 52 patients with ultrasound with the diagnosis phthisis bulbi. There are also reports of phthisical eyes found to have malignant tumors such as osteogenic sarcoma and uveal melanoma. Phthisis bulbi as a result of some suppurative traumatic or nontraumatic uveal inflammation is not a very rare condition, but shrinking of the globe as a result of uveal inflammation in utero is very rare indeed, and deserves to be recorded in medical literature.
Contributors ah was involved in the collection and analysis of the data. To determine the risk factors for the development of phthisis bulbi in severe ocular trauma patients with ccd based on the analysis of clinical course and treatment outcomes. Phthisis bulbi represents an ocular endstage disease that results from wound healing secondary to various causes such as severe trauma, inflammation, necrotizing tumors, andor vascular diseases. Ultraviolet radiationinduced corneal degeneration in 129 mice. Alvi, mdse king georges medical university up, lucknow, india prosthetic rehabilitation of phthisis bulbi defects is the only treatment option for cosmetic. Phthisis bulbi adalah kondisi mata yang ditandai dengan kerusakan mata yang parah. Typically disorganization of intraocular contents, opaque media, corneal scars, exudate in anterior and posterior chambers, advanced cataracts, destruction of vitreous, scleral thickening, cyclitic membrane extends from one ciliary body behind the lens to the other ciliary body, complete detachment of retina. Choroidal melanoma presenting with anterior segment. Examination revealed an irregular, black, fleshy, lobulated mass with vascularisation extending medially up to the inner canthus figure 1. Phthisis bulbi figure 1, figure 2, figure 3, and figure 4 is the diagnostic term used for the endstage eye morphology resulting from severe injury from various causes, such as trauma, inflammation, excess exposure to ionizing radiation or ambient light, or physical compression by space. Phthisis bulbi is a relatively uncommon and atypical clinical presentation of retinoblastoma. The case which i am reporting has been carefully differentiated from other congenital abnormalities, such as microphthalmus and.
Maxillofacial prostheses which restore and replace stomatognathic and associated facial structures with artificial substitutes aim to improve the patient aesthetics, restore and maintain health of the remaining structures and consequently provide. Srjg was involved in the drafting and the formulation of the data. Additional ocular diseases included traumatic ocular injuries nine globes from eight animals, phthisis bulbi nine globes from eight pinnipeds, neoplasia nine globes from six adult california sea lions, amyloid. Anatomy histology grossing acanthamoeba actinic band keratopathy aphakic bullous keratopathy blood staining bullous keratopathy calcific band keratopathy chronic actinic keratopathy collagenrich crystalloids corneal dystrophy epithelial ingrowth fuchs dystrophy graft failure herpes simplex keratitis infectious keratitis keratoconus. The diagnosis of pthisis bulbi was reconfirmed in 27 cases. Enophthalmus is a displacement of the eyeball backwards into the orbit. A retrospective survey of the ocular histopathology of the pinniped eye with emphasis on corneal disease iaaam 2010. Malignant melanoma and massive retinal gliosis in phthisis bulbi. Phthisis bulbi represents an ocular endstage disease that results from wound healing secondary to various. It results in vision loss and continues to be an important cause of blindness. Chicago, illinois norries disease congenital progressive oculoacousticocerebral dysplasia is a rare, genetically determined syndrome character ized by bilateral congenital amaurosis asso ciated with varying degrees of hearing im pairment and mental retardation.1129 86 1486 1342 1006 1210 1489 772 592 1288 41 1305 1568 1438 434 718 1155 434 1355 437 339 1563 1382 1308 761 424 1011 668 243